web and graphic design
I've been working with Photoshop since 2001, way back in the days of Photoshop 5.5. However, in the last couple of years, I've gotten a lot more serious about learning how to use Photoshop's full capabilities - ranging from animation to layers control - and in bringing in principles of art learned in Drawing and Design classes.
While Photoshop is widely considered the major player in raster graphics software, and is the one I know best, I also have familiarity with The GIMP and Corel Painter.